Tirzepatide (LY-3298176) is a dual agonist ofglucose-dependent polypeptide (GIP) (EC50=0.042 nM) andglucagon-like peptide-1 (GLP-1) (EC50=0.086 nM) receptors, and it has neuroprotective activity. It can improve blood pressure and lower low-density lipoprotein (LDL) cholesterol and triglycerides, and can be used to study diabetes and obesity.