麻生明
复旦大学教授、中国科学院上海有机化学研究所研究员 中国科学院院士，发展中国家科学院院士，国家杰青、教育部长江学者奖励计划特聘教授
联烯及其类似物的研究，包括合成、反应性、目标分子合成中的应用和生物活性等；以氧气为氧化剂的高选择性清洁氧化反应研究
分野から専門家を探す
化学・化学工学の全分野を網羅し、お客様のニーズに正確にマッチします。
化学名誉殿堂
世界を変えた化学の先駆者たちに敬意を表して
トップエキスパート
世界トップクラスの化学者とつながる
麻生明
中国科学院院士，发展中国家科学院院士，国家杰青、教育部长江学者奖励计划特聘教授
复旦大学教授、中国科学院上海有机化学研究所研究员
研究方向: 联烯及其类似物的研究，包括合成、反应性、目标分子合成中的应用和生物活性等；以氧气为氧化剂的高选择性清洁氧化反应研究
唐勇
中国科学院院士、国家杰出青年、新世纪百千万人才工程国家级人选、中国化学会科普工作委员会主任
中国科学院上海有机化学研究所所长
研究方向: 后过渡烯烃催化剂的设计、合成及可控性聚合、主族元素化合物的化学、不对称催化
涂永强
中国科学院院士、上海交通大学双聘院士、长江学者特聘教授、国家杰出青年基金获得者、中国化学会青年化学奖、香港求是基金会"杰出青年学者奖"、全国优秀科技工作者
兰州大学化学化工学院教授、博士生导师
研究方向: 有机合成方法、天然产物合成和金属有机化学
席振峰
中国科学院院士、北京大学博雅讲席教授、北京分子科学国家实验室（筹）共同主任、中国科学院分子识别与功能
北京大学化学与分子工程学院特聘教授、博士生导师
研究方向: 金属有机化学/氮气的活化与转化/配位化学、光化学与电化学
専门家インタビュー
トップランナーの思考に触れる
中试基地的角色与价值——从反哺基础研究到驱动产业化落地
对话手性催化探索——从学术传承到技术落地的多维突破
从辐射化学到氨氢能源——高分子材料的跨界创新之路
从分子设计到工业应用——负载型催化剂的破局与未来
AI重塑催化科学——从机理自动发现到精准设计的智能跃迁
从基于分片的静电模型到机器学习
CJC インタビュー
中国化学会 (CJC) 執筆者との今日の話題とインタビュー。
Chemical Measurement and Analysis: from Phenomenon to Essence
The review summaries our achievements in optical, electrochemical, as well as mass spectrometry analysis and imaging with high sensitivity, specificity, and spatiotemporal resolution. We promoted the plasmonic imaging system, and developed ultra-sensitive plasmonic nanoprobes for the tracking of single molecules in single living cells, as well as plasmonic nanocatalysts for highly efficient energy conversion. In addition, we contributed a lot in electrogenerated chemiluminescence (ECL) analysis and imaging. Pioneering works including localized surface plasmon resonance (LSPR) enhanced ECL, ECL ratiometric detection, BPE based ECL system, multi-color ECL sensing as well as super-resolved ECL imaging have been initiated by our group. Furthermore, we also dedicated in nanopipette based electrochemical analysis in single living cells, as well as ESI-MS analysis on short time scale. The research works of our group promoted the development of chemical measurement and analysis.
Polymersomes: From Macromolecular Self-Assembly to Particle Assembly
Polymersomes, or polymer vesicles, have attracted a tremendous amount of interest over the last decade. This led to the development of polymer vesicles that are suitable for various biomedical applications, including blood sugar regulation, cancer theranostics, and antibacterial agents. This review mainly describes the research from our group on macromolecular self-assembly of polymersomes and emerging particle assembly methods. First, the building blocks and general principles for the design of functional polymersomes are introduced. Thereafter, we present three polymersomes with various membrane structures: polymersomes with inhomogeneous membranes, asymmetrical coronas, and membranes that are fused with the coronas. Furthermore, given that N-carboxyanhydrides-induced self-assembly (NCA-PISA) is a convenient method for the large-scale production of biodegradable polymersomes, recent advances in self-assembly methods based on ring-opening polymerization of NCA-PISA are discussed. Fina
Stretchable Electrochemical Sensors: From Electrode Fabrication to Cell Mechanotransduction Monitoring
Electrochemical sensing faces huge challenges in characterizing the transient release of biochemical molecules from deformed cells, due to the severely mechanical mismatch between rigid electrodes and soft cells. In recent years, the emergence of stretchable electrochemical sensors has made a breakthrough by complying with the deformation of living cells and simultaneous monitoring of mechanically evoked biochemical signals. This review first summarizes two fundamental strategies for the fabrication of stretchable electrodes from the points of structure and material. Next, recent progresses in construction of functionalized interface to improve the performance of stretchable electrochemical sensors are presented. Then, the application of stretchable electrochemical sensors in real-time monitoring of biomolecules released by mechanically sensitive cells is introduced. Finally, some perspectives and challenges of stretchable electrochemical sensors regarding cell detection are discussed.
Vapor-Phase Precise-Synthesis of 2D Inorganic Materials for Optoelectronics
2D materials have attracted intensive attention due to their unique electrical and optical properties associated with their strictly defined low dimensionalities. They provide a wide range of basic building blocks for future electronics and optoelectronics. The chemical vapor deposition (CVD) has been proposed to be efficient to realize the controllable thickness, scalable size, which are necessary for both industrial applications and fundamental researches. Herein, we share our research works to realize the controllable growth of 2D materials. We found that stable growth microenvironment can regulate the growth of 2D materials. Thus, we developed near-steady source supply, space-confined, and additive-assisted passivated growth methods to solve the problem of unstable growth environment caused by uneven source and mass transfer. Then, we developed several strategies to precisely control the parity, separation, and transport of the carriers in 2D materials including fabricating defect-
Pd-Catalyzed Asymmetric Allylic C—H Functionalization
Pd-catalyzed asymmetric allylic C—H functionalization has emerged as a powerful tool to access chiral, densely functionalized molecules from easily accessible alkenes, enabling the increase of the step- or atom-economy by minimizing functional group manipulations for preparing allylating reagents. Due to the inadequacy of stereoselection strategies, the asymmetric allylic C—H functionalization is still in the early stage. In this essay, we will describe our journey to identification of asymmetric catalytic systems, mechanism of allylic C—H activation, control of stereo- and regioselectivity, and applications in asymmetric synthesis.
A Nearly 20-Year Journey to Success of Azvudine for Antiviral Therapy
Modified nucleosides, particularly those with 4'-modifications, are significant nucleosides used in antiviral treatments. The drug discovery campaign of Azvudine starts from 2′-deoxynucleoside, followed by extensive modifications, such as introducing the 4’-position substitutions, a 2’-β-fluoro atom, and changing the nucleobases. Azvudine acts potently toward various HIV-1 strains by inhibiting HIV-1 reverse transcription and preventing Vif-induced A3G degradation, representing the first-in-class dual-acting antiviral agent. In July 2021, the NMPA conditionally approved Azvudine as an adjunct therapy for adult patients with high levels of HIV-1 virus load when combined with NRTIs or NNRTIs. Azvudine is capable of inhibiting SARS-CoV-2, as well as its variants, including Alpha, Beta, Delta, and Omicron. Clinical trials have revealed its real-world effectiveness among hospitalized severely or critically ill COVID-19 patients or those with pre-existing conditions.