2026全国化学化工产学研会议

A strategy based on sequential "C-H thianthrenation/Pd-catalyzed asymmetric Heck reaction" was designed to synthesize trisubstituted chiral allenes from non-prefunctionalized arenes directly. This innovative approach successfully addressed challenging cyclic and acyclic systems while enabling late-stage modification of complex small molecules. The methodology exhibited remarkable robustness through its successful implementation in a gram-scale reaction and the recycling of thianthrene (TT). Density functional theory (DFT) computation results reveal that the enantioselective step follows a base-accelerated β-H elimination mechanism..